Our Requests for Applications
Seed Grants
Description: These grants fund preliminary ALS research that will support funding applications from other sources for larger scale and more impactful research projects.
Funding: Up to $50,000 over 1 year
This opportunity has closed.
The Hoffman ALS Clinical Trial Awards Program
Description: This program supports early- to mid-stage (phase 1 or 2a) interventional clinical trials of novel or repositioned therapeutics for ALS.
Funding: Up to $1,000,000 over 2–3 years
This opportunity has closed.
Milton Safenowitz Postdoctoral Fellowship Program
Description: This program supports the development of early career scientists by funding junior postdoctoral fellows doing research of high scientific merit and relevance to ALS.
Funding: Up to $150,000 over 2 years
This opportunity has closed.
The Lawrence and Isabel Barnett Drug Development Program
Description: This program supports the preclinical development of new or repurposed treatments for ALS.
Funding: Up to $500,000 over 2 years
This opportunity has closed.
Learn About Our Awards and Programs
Additional Funding Opportunities
Clinical Outcomes and Biomarkers Award
Funding Organization: Department of Defense ALS Research Program
Description: This award supports the development and/or validation of clinical outcomes and biomarkers to enrich ALS clinical trials. Projects can be relevant to a specific therapy, class of therapeutics, or specific ALS subtype (such as a particular genetic mutation).
Available Funding: $750,000 for direct costs for the entire three-year period of performance
Application Deadline: July 10, 2024, 11:59 p.m. ET
Pilot Clinical Trial Award Program
Funding Organization: Department of Defense ALS Research Program
Description: This program supports phase 1 or small-scale phase 2 trials investigating safety, feasibility, biomarker application, and therapeutic efficacy in relevant patient populations. These trials can evaluate promising drugs, biologics, or devices or be aimed at improving aspects of patient care and ALS symptom management.
Available Funding: $2,000,000 for direct costs for the entire four-year period of performance
Application Deadline: July 10, 2024, 11:59 p.m. ET
Therapeutic Development Award Program
Funding Organization: Department of Defense ALS Research Program
Description: This program supports secondary preclinical validation and/or IND-enabling studies of therapeutics for ALS. Applications supported by this award must begin with lead compounds in hand and include proof-of-concept efficacy data in at least one preclinical model system of ALS, including whole animal and cellular model systems.
Available Funding: $1,500,000 for direct costs for the entire three-year period of performance
Application Deadline: July 10, 2024, 11:59 p.m. ET
Therapeutic Idea Award Program
Funding Organization: Department of Defense ALS Research Program
Description: This program supports new, innovative, high-risk, high-gain ideas aimed at ALS drug or therapy discovery. The studies supported by this program are expected to be hypothesis-driven and generate preliminary data for future avenues of therapeutic investigation.
Available Funding: $600,000 for direct costs for the entire two-year period of performance
Application Deadline: July 10, 2024, 11:59 p.m. ET
2024 Sean M. Healey International Prize for Innovation in ALS
Funding Organization: Sean M. Healey & AMG Center for ALS
Description: This global prize celebrates excellence in research for a team of investigators who have catalyzed exceptional discoveries that have led to a transformative advance in therapy development in ALS.
Prize: $50,000 and travel reimbursement up to $2,500 to attend the International Symposium on ALS/MND
Nominations Due: July 26, 2024, 5 p.m. ET
Drs. Ayeez and Shelena Lalji & Family ALS Endowed Award for Innovative Healing
Funding Organization: Sean M. Healey & AMG Center for ALS
Description: This annual, global prize recognizes an individual or team for excellence in their transformative scientific discoveries focused on repair and regeneration of neurological function in ALS.
Available Funding: $40,000 and travel reimbursement up to $2,500 to attend the International Symposium on ALS/MND
Nominations Due: August 23, 2024, 5 p.m. ET
Clinical Studies of Orphan Products Addressing Unmet Needs of Rare Diseases (R01)
Funding Organization: U.S. Food and Drug Administration
Description: This program funds clinical trials evaluating the efficacy and/or safety of existing products in support of a new indication or change in labeling to address unmet needs in rare diseases or conditions, such as ALS.
Available Funding: Up to $650,000 per year for four years
Open Date: August 23, 2024
Clinical Research Training Scholarship in ALS
Funding Organizations: The ALS Association and American Brain Foundation in collaboration with the American Academy of Neurology
Description: This award aims to recognize the importance of good clinical research and to encourage early career investigators in clinical studies in ALS. Recipient must be an AAN member interested in an academic career in neurological research who has completed residency or a Ph.D. no more than five years prior to the beginning of this award (July 1, 2025).
Available Funding: $65,000 per year for two years, plus a $10,000 per year stipend to support education and research-related costs
Application Deadline: September 10, 2024
Richard Olney Clinician Scientist Development Award in ALS
Funding Organizations: The ALS Association and American Brain Foundation in collaboration with the American Academy of Neurology
Description: This award recognizes the importance of good clinical research and encourages early career investigators in clinical studies in ALS. Recipient must be an AAN member interested in an academic career in neurologic research who has completed residency or a Ph.D. no more than seven years prior to the beginning of this award (July 1, 2025).
Available Funding: $75,000 per year for three years, plus a $5,000 per year stipend to support education and research-related costs
Application Deadline: September 10, 2024
Clinical Studies of Orphan Products Addressing Unmet Needs of Rare Diseases (R01)
Funding Organizations: U.S. Food and Drug Administration (FDA)
Description: The purpose of this opportunity is to fund clinical trials (Phase 1, 2, and/or 3) of products evaluating efficacy and/or safety in support of a new indication or change in labeling to address unmet needs in rare diseases or conditions.
Available Funding: Up to $650,000 per year for up to four years; applicants may request up to an additional $250,000 total costs per year (to a maximum total award cost of $900,000 per year) for innovative and efficient trial approaches.
Application Deadline: October 22, 2024, 11:59 p.m. ET
Sheila Essey Award for ALS Research
Funding Organizations: The ALS Association, American Academy of Neurology, and American Brain Foundation
Description: This award recognizes an individual who has made significant research contributions in the search for the cause, prevention of, and cure for ALS. The criteria being used to determine the recipient include recent major scientific impact, long-term scientific impact, and overall impact to ALS.
Prize: $50,000 to continue ALS research and complimentary registration for the American Academy of Neurology’s 2025 Annual Meeting
Application Deadline: October 31, 2024, 11:59 p.m. CT
Want to add your funding opportunity to this list? Contact us at ResearchGrants@als.org.
